Dissecting the diverse functions of the metastasis suppressor CD82/KAI1

► CD82 inhibits multiple steps of the metastatic process. ► CD82 suppresses metastasis by regulating partner protein trafficking and cell membrane dynamics. ► Transcriptional regulation of CD82 is altered in cancer cells. ► Post-translational regulation by the ubiquitin-proteasome system contributes to loss of CD82 in cancer cells.