Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppression

► BRMS1, first identified in 2000,suppresses metastasis of multiple types of cancer. ► BRMS1 associates with large SIN3 chromatin remodeling complexes. ► BRMS1 is epigenetically regulated by promoter methylation. ► Metastasis associated molecular pathways are coordinately regulated by BRMS1.