siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells

► ARNT2 can affect HIF-1-regulated signaling and metabolism in MCF7 cells. ► Knockdown of ARNT2 expression inhibited VHL, HIF-1α and Glut-3 expression. ► Knockdown of ARNT2 expression induced SAG expression. ► Knockdown of ARNT2 expression impaired glycine synthesis and glucose metabolism.