Iron influences the abundance of the iron regulatory protein Cir1 in the fungal pathogen Cryptococcus neoformans

► The fungus Cryptococcus neoformans is an important pathogen of AIDS patients. ► The transcription factor Cir1 regulates iron uptake and virulence in C. neoformans. ► We examined the influence of iron levels on the abundance of Cir1. ► Iron deprivation results in reduced abundance of Cir1. ► Cir1 stability is also regulated by redox conditions and proteasome activity.