کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10871811 | 1074085 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
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چکیده انگلیسی
In mammals, complex I (NADH-ubiquinone oxidoreductase) of the mitochondrial respiratory chain has 31 supernumerary subunits in addition to the 14 conserved from prokaryotes to humans. Multiplicity of structural protein components, as well as of biogenesis factors, makes complex I a sensible pace-maker of mitochondrial respiration. The work reviewed here shows that the cAMP/PKA pathway regulates the biogenesis, assembly and catalytic activity of complex I and mitochondrial oxygen superoxide production. The structural, functional and regulatory complexity of complex I, renders it particularly vulnerable to genetic and sporadic pathological factors. Complex I dysfunction has, indeed, been found, to be associated with several human diseases. Knowledge of the pathogenetic mechanisms of these diseases can help to develop new therapeutic strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 5, 9 March 2012, Pages 568-577
Journal: FEBS Letters - Volume 586, Issue 5, 9 March 2012, Pages 568-577
نویسندگان
Sergio Papa, Domenico De Rasmo, Zuzana Technikova-Dobrova, Damiano Panelli, Anna Signorile, Salvatore Scacco, Vittoria Petruzzella, Francesco Papa, Giuseppe Palmisano, Antonio Gnoni, Loris Micelli, Anna Maria Sardanelli,