کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10871830 1074087 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
When the caps fall off: Responses to telomere uncapping in yeast
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
When the caps fall off: Responses to telomere uncapping in yeast
چکیده انگلیسی
Telomeres protect the ends of linear chromosomes from activities that cause sequence losses or challenge chromosome integrity. Furthermore, these ends must be hidden from detection by the DNA damage recognition and response pathways. In particular, they must not fuse with each other. These fundamental and very first functions attributed to telomeres are also summarized with the term 'chromosome capping'. However, telomeres can become uncapped and the foremost cellular responses to such events aim to restore genome stability in the most conservative fashion possible. I will provide an outline of cellular responses to uncapping in budding yeast and briefly discuss the reverse, namely avoidance mechanisms that prevent telomere formation at inappropriate places.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 17, 10 September 2010, Pages 3734-3740
نویسندگان
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