کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872018 | 1074095 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dcp1a phosphorylation along neuronal development and stress
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Decapping protein 1a (Dcp1a) is found in P-bodies and functions in mRNA cap removal prior to its degradation. The function and binding partners of Dcp1a have been thoroughly studied, however its expression pattern is still unclear. In this study we have monitored Dcp1a expression along brain development, neuronal differentiation and during cellular stress. We found that Dcp1a is hyperphosphorylated under these physiological conditions. We followed our observations and identified the specific amino acid residues that are phosphorylated. These findings suggest a novel post-translational modification that may influence the function of Dcp1a in response to various physiological cues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 1, 5 January 2009, Pages 197-201
Journal: FEBS Letters - Volume 583, Issue 1, 5 January 2009, Pages 197-201
نویسندگان
Jacob Blumenthal, Leah Behar, Evan Elliott, Irith Ginzburg,