Recognition of the ligand-type specificity of classical and non-classical MHC I proteins

► The ligand-type specificity of MHC I proteins (P, L, N) cannot be distinguished on the sequence space. ► SVM and kNN classifiers predict the ligand-type specificity of MHC I proteins with great accuracy. ► The ligand-type specificity of various uncharacterized MHC Ib proteins has been predicted.