کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872206 1074111 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Something worth dyeing for: Molecular tools for the dissection of lipid metabolism in Caenorhabditis elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Something worth dyeing for: Molecular tools for the dissection of lipid metabolism in Caenorhabditis elegans
چکیده انگلیسی
The nematode Caenorhabditis elegans (C. elegans) has during the last decade emerged as an invaluable eukaryotic model organism to understand the metabolic and neuro-endocrine regulation of lipid accumulation. The fundamental pathways of food intake, digestion, metabolism, and signalling are evolutionary conserved between mammals and worms making C. elegans a genetically and metabolically extremely tractable model to decipher new regulatory mechanisms of lipid storage and to understand how nutritional and genetic perturbations can lead to obesity and other metabolic diseases. Besides providing an overview of the most important regulatory mechanisms of lipid accumulation in C. elegans, we also critically assess the current methodologies to monitor lipid storage and content as various methods differ in their applicability, consistency, and simplicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 11, 3 June 2010, Pages 2183-2193
نویسندگان
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