کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872253 | 1074111 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 11, 3 June 2010, Pages 2473-2477
Journal: FEBS Letters - Volume 584, Issue 11, 3 June 2010, Pages 2473-2477
نویسندگان
Ran Brosh, Rachel Sarig, Elad Bar Natan, Alina Molchadsky, Shalom Madar, Chamutal Bornstein, Yosef Buganim, Tirosh Shapira, Naomi Goldfinger, Ralf Paus, Varda Rotter,