کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872327 1074115 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells
چکیده انگلیسی
RIG-G is a retinoic acid- or interferon-induced gene with potential anti-proliferation function. However, the mechanism underlying ATRA-induced RIG-G induction is not completely understood. Here, we demonstrate that ATRA up-regulates the expression of PU.1, which in turn directly binds to the promoter and increases the expression of RIG-G gene. Luciferase reporter assay and electrophoretic mobility shift assay reveal that PU.1 preferentially binds to one of the two putative binding sites on the RIG-G promoter. Moreover, silencing of PU.1 by shRNA markedly inhibited ATRA- but not IFNα-induced expression of RIG-G. These data provide new insight into the mechanism of ATRA-induced RIG-G expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 2, 21 January 2011, Pages 375-380
نویسندگان
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