کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872342 1074129 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the role of the chaperonin CCT in the just-in-time assembly process of APC/CCdc20
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
On the role of the chaperonin CCT in the just-in-time assembly process of APC/CCdc20
چکیده انگلیسی
The just-in-time hypothesis relates to the assembly of large multi-protein complexes and their regulation of activation in the cell. Here I postulate that chaperonins may contribute to the timely assembly and activation of such complexes. For the case of anaphase promoting complex/cyclosomeCdc20 assembly by the eukaryotic chaperonin chaperonin containing Tcp1 it is shown that just-in-time synthesis and chaperone-assisted folding can synergise to generate a highly regulated assembly process of a protein complex that is vital for cell cycle progression. Once dependency has been established transcriptional regulation and chaperonin-dependency may have co-evolved to safeguard the timely activation of important multi-protein complexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 3, 5 February 2010, Pages 477-481
نویسندگان
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