کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872446 | 1074141 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method](/preview/png/10872446.png)
چکیده انگلیسی
Somatic angiotensin I-converting enzyme (s-ACE) plays a central role in blood pressure regulation and has been the target of most antihypertensive drugs. A displacement isothermal titration calorimetry method has been used to accurately determine the binding constant of three strong s-ACE inhibitors. Under the experimental conditions studied in this work, the relative potency of the inhibitors was determined to be enalaprilat > lisinopril > captopril. We analyze the thermodynamic behaviour of the binding process using the new structural information provided by the ACE structures, as well as the conformational changes that occur upon binding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 18, 24 July 2007, Pages 3449-3454
Journal: FEBS Letters - Volume 581, Issue 18, 24 July 2007, Pages 3449-3454
نویسندگان
Montserrat Andújar-Sánchez, Vicente Jara-Pérez, Ana Cámara-Artigas,