کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872483 1074148 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cells and prions: A license to replicate
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Cells and prions: A license to replicate
چکیده انگلیسی
Prion diseases are neurodegenerative, infectious disorders characterized by the aggregation of a misfolded isoform of the cellular prion protein (PrPC). The infectious agent - termed prion - is mainly composed of misfolded PrPSc. In addition to the central nervous system prions can colonize secondary lymphoid organs and inflammatory foci. Follicular dendritic cells are important extraneural sites of prion replication. However, recent data point to a broader range of cell types that can replicate prions. Here, we review the state of the art in regards to peripheral prion replication, neuroinvasion and the determinants of prion replication competence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 16, 20 August 2009, Pages 2674-2684
نویسندگان
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