کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872827 | 1074252 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Matrix Mg2+ regulates mitochondrial ATP-dependent potassium channel from heart
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Matrix Mg2+ regulates mitochondrial ATP-dependent potassium channel from heart Matrix Mg2+ regulates mitochondrial ATP-dependent potassium channel from heart](/preview/png/10872827.png)
چکیده انگلیسی
Mitochondrial ATP-regulated potassium (mitoKATP) channels play an important role in cardioprotection. Single channel activity was measured after reconstitution of inner mitochondrial membranes from bovine myocardium into a planar lipid bilayer. After incorporation, the potassium channel was recorded with a mean conductance of 103 ± 9 pS. The channel activity was inhibited by ATP/Mg and activated by GDP. Magnesium ions alone affected, in a dose dependent manner, both the channel conductance and the open probability. Magnesium ions regulated the mitoKATP channel only when added to the trans compartment. We conclude that Mg2+ regulates the cardiac mitoKATP channel from the matrix site by affecting both the channel conductance and gating.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 7, 14 March 2005, Pages 1625-1632
Journal: FEBS Letters - Volume 579, Issue 7, 14 March 2005, Pages 1625-1632
نویسندگان
Piotr Bednarczyk, Krzysztof DoÅowy, Adam Szewczyk,