کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10873377 1074277 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extracellular copper ions regulate cellular prion protein (PrPC) expression and metabolism in neuronal cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Extracellular copper ions regulate cellular prion protein (PrPC) expression and metabolism in neuronal cells
چکیده انگلیسی
The physiological functions of cellular prion protein (PrPC) remain unclear. It has been demonstrated that PrPC is a copper binding protein and proposed that its functions could be strictly linked to copper metabolism and neuroprotection. The aim of this study was to clarify how extracellular copper modifies PrPC expression and metabolism in cultured neurones. We reported here that copper delivered at physiological concentrations significantly decreases PrPC mRNA expression in GN11 neurones. Moreover, copper increases the release of PrPC into the culture medium. These results indicate that extracellular copper strongly affects the amount of cellular PrP and might represent an interesting strategy to decrease the expression of PrPC in neurones and its conversion in the pathological isoform PrPSc.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 3, 31 January 2005, Pages 741-744
نویسندگان
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