Development of a rational nomenclature for naming peptide and protein toxins from sea anemones

► New systematic nomenclature is a clear method for rename all sea anemone peptide and protein toxins. ► New names reflect biological activity, origin, and relationship among toxin isoforms. ► Phylogenetic analysis by global alignment defined cut-off values of identity and similarity to identify toxin isoforms. ► New nomenclature represents an ongoing challenge to identify and classify sea anemone toxins.