کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10879944 | 1076883 | 2012 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Renal effects and injury induced by animal toxins
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
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چکیده انگلیسی
Animal toxins are well recognized for their hazards to man. Consisting of peptides, enzymes, chemicals and proteins, animal toxins can cause cellular injury with a broad spectrum of clinical manifestations. The kidney, as a highly vascularized organ, is vulnerable to toxin injury by either hemodynamic alterations which lead to renal ischemia or by direct kidney injury. Hemodynamic changes can be induced by toxin effects on ion channels, or by peptides and enzymes. Hemodynamic changes, inflammatory and vasoactive mediators and direct nephrotoxicity are tightly intregrated in causing renal injury. Several animal toxin components are involved in renal injury. Effects of toxins on renal tubular epithelial transport, a rather neglected area, and serum electrolyte changes in the victims are brought to attention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 60, Issue 5, October 2012, Pages 943-953
Journal: Toxicon - Volume 60, Issue 5, October 2012, Pages 943-953
نویسندگان
Visith Sitprija, Siravit Sitprija,