Heminecrolysin, the first hemolytic dermonecrotic toxin purified from scorpion venom

► Hemiscorpious lepturus scorpion envenomation shares common clinical features with spider's. ► Heminecrolysin is the first dermonecrotic toxin purified from scorpion venom. ► Trypsin digest and MS/MS analysis showed homology with brown spider sphingomyelinase D. ► Pharmalogical characterization indicate sphingomyelinase D, complement-dependent hemolysis and dermonecrosis activities.