Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell migration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28

► r-Rub is a potent apoptotic inducer of SK-Mel-28, but not T24 or HeLA cells. ► r-Rub also inhibits cell migration and proliferation of SK-Mel-28. ► It is possible that some of the cell proliferation inhibition may be due to apoptosis. ► It is likely that atrolysin E, the closest homolog to rubistatin, shares similar activities.