کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10880403 1076965 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polyclonal antibodies against native weak toxin Naja kaouthia discriminate native weak toxins and some other three-fingered toxins against their denaturated forms
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Polyclonal antibodies against native weak toxin Naja kaouthia discriminate native weak toxins and some other three-fingered toxins against their denaturated forms
چکیده انگلیسی
Polyclonal antibodies obtained by immunization of rabbits with native form of weak toxin (WTX) from cobra Naja kaouthia venom efficiently interacted with WTX and a weak toxin from Naja oxiana venom, but not so with their denaturated forms. These antibodies could also bind with lower affinity other groups of three-fingered toxins: long-chain α-neurotoxins, muscarinic toxins and cytotoxins, but practically did not bind short-chain α-neurotoxins. The efficiency of toxin-antibody interaction depends on the group (weak toxins, long or short α-neurotoxins, cytotoxins etc.) to which the toxin belongs, but not on species of snake from which the toxin originates. There is a correlation between the results obtained and phylogenetic analysis of the three-fingered toxins which revealed that WTX is very close to other weak toxins, relatively close to long α-neurotoxins, cytotoxins and muscarinic toxins, but is distant from the short α-neurotoxins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 46, Issue 1, July 2005, Pages 24-30
نویسندگان
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