کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10880403 | 1076965 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polyclonal antibodies against native weak toxin Naja kaouthia discriminate native weak toxins and some other three-fingered toxins against their denaturated forms
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
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چکیده انگلیسی
Polyclonal antibodies obtained by immunization of rabbits with native form of weak toxin (WTX) from cobra Naja kaouthia venom efficiently interacted with WTX and a weak toxin from Naja oxiana venom, but not so with their denaturated forms. These antibodies could also bind with lower affinity other groups of three-fingered toxins: long-chain α-neurotoxins, muscarinic toxins and cytotoxins, but practically did not bind short-chain α-neurotoxins. The efficiency of toxin-antibody interaction depends on the group (weak toxins, long or short α-neurotoxins, cytotoxins etc.) to which the toxin belongs, but not on species of snake from which the toxin originates. There is a correlation between the results obtained and phylogenetic analysis of the three-fingered toxins which revealed that WTX is very close to other weak toxins, relatively close to long α-neurotoxins, cytotoxins and muscarinic toxins, but is distant from the short α-neurotoxins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 46, Issue 1, July 2005, Pages 24-30
Journal: Toxicon - Volume 46, Issue 1, July 2005, Pages 24-30
نویسندگان
E.V. Kryukova, D.Yu. Mordvintsev, S. Daya, Yu.N. Utkin, V.I. Tsetlin,