Parkinson's disease-like neuromuscular defects occur in prenyl diphosphate synthase subunit 2 (Pdss2) mutant mice

► Pdss2 deficient mice exhibit severe neuromuscular defects as demonstrated by behavioral testing. ► Marked reduction in TH-positive cells in the substantia nigra reflects neuromuscular impairment. ► Probucol prevented kidney disease, but not neuromuscular phenotypes, in Pdss2 missense mutants.