کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10883616 1078475 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Towards a computational reconstruction of the electrodynamics of premature and full term human labour
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Towards a computational reconstruction of the electrodynamics of premature and full term human labour
چکیده انگلیسی
We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Biophysics and Molecular Biology - Volume 107, Issue 1, October 2011, Pages 183-192
نویسندگان
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