کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10883730 | 1078622 | 2005 | 50 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proteins that bind high-mannose sugars of the HIV envelope
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Proteins that bind high-mannose sugars of the HIV envelope Proteins that bind high-mannose sugars of the HIV envelope](/preview/png/10883730.png)
چکیده انگلیسی
A broad range of proteins bind high-mannose carbohydrates found on the surface of the envelope protein gp120 of the human immunodeficiency virus and thus interfere with the viral life cycle, providing a potential new way of controlling HIV infection. These proteins interact with the carbohydrate moieties in different ways. A group of them interacts as typical C-type lectins via a Ca2+ ion. Another group interacts with specific single, terminal sugars, without the help of a metal cation. A third group is involved in more intimate interactions, with multiple carbohydrate rings and no metal ion. Finally, there is a group of lectins for which the interaction mode has not yet been elucidated. This review summarizes, principally from a structural point of view, the current state of knowledge about these high-mannose binding proteins and their mode of sugar binding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Biophysics and Molecular Biology - Volume 88, Issue 2, June 2005, Pages 233-282
Journal: Progress in Biophysics and Molecular Biology - Volume 88, Issue 2, June 2005, Pages 233-282
نویسندگان
Istvan Botos, Alexander Wlodawer,