کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10891344 | 1082007 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stem cell integrins: Implications for ex-vivo culture and cellular therapies
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کلمات کلیدی
ECMHSCIGFintracellular cell adhesion moleculeNSCVCAMbFGFICAMICMmESCMSCERKhESC - hescMitogen activated protein kinase kinase - Mitogen فعال پروتئین کیناز کینازInner cell mass - توده سلولی داخلیMouse embryonic stem cell - سلول بنیادی جنینی موشhaematopoietic stem cell - سلول بنیادی خون شناسیhuman embryonic stem cells - سلول های بنیادی جنینی انسانNeural stem cell - سلول های بنیادی عصبیMesenchymal stem cell - سلول های بنیادی مزانشیمیbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایهInsulin-like growth factor - فاکتور رشد مانند انسولینExtracellular matrix - ماتریکس خارج سلولیMEK - مجاهدین خلقvascular cell adhesion molecule - مولکول چسبندگی سلولی عروقیextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیRho-associated kinase - کیناز وابسته به RhoRock - یا راک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
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چکیده انگلیسی
Use of stem cells, whether adult or embryonic for clinical applications to treat diseases such as Parkinson's, macular degeneration or Type I diabetes will require a homogenous population of mature, terminally differentiated cells. A current area of intense interest is the development of defined surfaces for stem cell derivation, maintenance, proliferation and subsequent differentiation, which are capable of replicating the complex cellular environment existing in vivo. During development many cellular cues result from integrin signalling induced by the local extracellular matrix. There are 24 known integrin heterodimers comprised of one of 18 α subunits and one of 8 β subunits and these have a diverse range of functions mediating cell-cell adhesion, growth factor receptor responses and intracellular signalling cascades for cell migration, differentiation, survival and proliferation. We discuss here a brief summary of defined conditions for human embryonic stem cell culture together with a description of integrin function and signalling pathways. The importance of integrin expression during development is highlighted as critical for lineage specific cell function and how consideration of the integrin expression profile should be made while differentiating stem cells for use in therapy. In addition this review summarises the known integrin expression profiles for human embryonic stem cells and 3 common adult stem cell types: mesenchymal, haematopoietic and neural. We then outline some of the possible technologies available for investigating cell-extracellular matrix interactions and subsequent integrin mediated cell responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Stem Cell Research - Volume 6, Issue 1, January 2011, Pages 1-12
Journal: Stem Cell Research - Volume 6, Issue 1, January 2011, Pages 1-12
نویسندگان
Andrew B.J. Prowse, Fenny Chong, Peter P. Gray, Trent P. Munro,