Conventional allograft and autograft in low grade lymphoma

Nevertheless, allogeneic stem cell transplantation (Allo SCT) appears to provide the best/highest chances for cure, providing a non-contaminated graft along with a graft versus lymphoma (GVL) effect. However, the procedure is age limited due to its high toxicity, (especially in patients over 50 years), limiting this procedure to younger patients whose life expectancy due to disease is short. Reduced intensity SCT may therefore be a reasonable approach in younger patients with advanced disease, allowing a GVL effect with less toxicity compared with conventional allograft. However, data is still limited and follow-up in the majority of studies is relatively short, highlighting the need for longer follow-up to establish the role of reduced intensity SCT in low grade lymphoma.