کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10895550 1083081 2015 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vaccination approach to anti-angiogenic treatment of cancer
ترجمه فارسی عنوان
رویکرد واکسیناسیون به درمان ضد سرطان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Improvement of patient survival by anti-angiogenic therapy has proven limited. A vaccination approach inducing an immune response against the tumor vasculature combines the benefits of immunotherapy and anti-angiogenesis, and may overcome the limitations of current anti-angiogenic drugs. Strategies to use whole endothelial cell vaccines and DNA- or protein vaccines against key players in the VEGF signaling axis, as well as specific markers of tumor endothelial cells, have been tested in preclinical studies. Current clinical trials are now testing the promise of this specific anti-cancer vaccination approach. This review will highlight the state-of-the-art in this exciting field of cancer research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1855, Issue 2, April 2015, Pages 155-171
نویسندگان
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