کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10899313 | 1084363 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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![عکس صفحه اول مقاله: Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients](/preview/png/10899313.png)
چکیده انگلیسی
Invasion and metastasis are major malignant characteristics of human gastric cancer (GC), but the underlying molecular mechanisms are poorly understood. Recent studies have shown that scinderin (SCIN), an actin severing and capping protein that regulates the actin cytoskeleton, is involved in the proliferation and migration of certain cancer cells. Accordingly, this study aimed to investigate the potential role of SCIN in the invasion and metastasis of human GC cells and to evaluate its prognostic value for GC patients. We found that high levels of SCIN expression in GC tumors were correlated with poor overall survival of patients. Silencing of SCIN effectively suppressed the migratory and invasive capabilities of human GC cells in vitro and tumorigenicity and metastasis in vivo. Furthermore, knockdown of SCIN markedly inhibited the formation of filopodia, decreasing GC cell migration and the expression of Cdc42, an important regulator of filopodia by GC cells. These findings suggest that SCIN may be a novel prognostic marker and a potential therapeutic target in human GC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 376, Issue 1, 28 June 2016, Pages 110-117
Journal: Cancer Letters - Volume 376, Issue 1, 28 June 2016, Pages 110-117
نویسندگان
Jia-jia Liu, Jun-yan Liu, Jun Chen, Yi-xi Wu, Peng Yan, Cheng-dong Ji, Yan-xia Wang, Dong-fang Xiang, Xia Zhang, Peng Zhang, You-hong Cui, Ji Ming Wang, Xiu-wu Bian, Feng Qian,