کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10899419 1084375 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of carrier cells on the clinical outcome of children with neuroblastoma treated with high dose of oncolytic adenovirus delivered in mesenchymal stem cells
ترجمه فارسی عنوان
تأثیر سلول های حامل بر نتایج بالینی کودکان مبتلا به نوروبلاستوما تحت درمان با دوز بالا از آدنوویروس اونولتیتیک تحویل داده شده در سلول های بنیادی مزانشیمی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
We report here our clinical experience of a program of compassionate use of Celyvir - autologous marrow-derived mesenchymal stem cells (MSCs) carrying an oncolytic adenovirus - for treating children with advanced metastatic neuroblastoma. Children received weekly doses of Celyvir with no concomitant treatments. The tolerance was excellent, with very mild and self-limited viral-related symptoms. Patients could be distinguished based on their response to therapy: those who had a clinical response (either complete, partial or stabilization) and those who did not respond. We found differences between patients who responded versus those who did not when analyzing their respective MSCs, at the expression levels of adhesion molecules (CCR1, CXCR1 and CXCR4) and in migration capacities in transwell assays, and in immune-related molecules (IFNγ, HLA-DR). These results suggest interpatient differences in the homing and immune modulation capacities of the therapy administered. In addition, the pretherapy immune T cell status and the T effector response were markedly different between responders and non-responders. We conclude that multidoses of Celyvir have an excellent safety profile in children with metastatic neuroblastoma. Intrinsic patients' and MSCs' factors appear to be related to clinical outcome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 371, Issue 2, 28 February 2016, Pages 161-170
نویسندگان
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