Metronomic chemotherapy: An attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance

- Metronomic chemotherapy involves administering lower doses of chemotherapeutic drugs at more frequent intervals.
- Lower dosage target supporting tumor stroma and circumvent selection for resistant cancer cells.
- Lower dosage and more frequent administration allow preservation and maintenance of anti-tumor immunity.
- Metronomic chemotherapy, despite slower initial decreases in tumor size, yields long-term improved clinical outcome.
- Cancer is a disease of both tumor cells and their microenvironment.