کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10899886 1084423 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cells
چکیده انگلیسی
The molecular mechanism of telomerase activation induced by ionizing radiation (IR) remains poorly understood. We demonstrate that DNA damage induced by IR at doses of 2-5 Gy triggers activation of Akt, predominant to that of protein phosphatase 2A (PP2A), resulting in human telomerase reverse transcriptase (hTERT) phosphorylation and increased telomerase activity in Y79 cells. DNA damage induced by IR at doses greater than 10 Gy might trigger PP2A activation, predominant to that of Akt, resulting in hTERT dephosphorylation and decreased telomerase activity. Our results suggest that differential activation of Akt and PP2A may be responsible for telomerase regulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 340, Issue 1, 28 October 2013, Pages 82-87
نویسندگان
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