Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo

►CoCl2 can induce formation of stem-like cells (PGCs or PGCCs) ► CoCl2 activates the expression of hemoglobins that may lead to formation of erythroid cells.► Fibroblasts and cancer cells may obtain O2 in response to hypoxia without angiogenesis. ► CoCl2 may be a useful agent in helping to generate unlimited red bllod cells in vitro.