TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways

► TACC3 has an ability to regulate cell proliferation, migration, invasion and transformation. ► Overexpression of TACC3 promotes EMT, at least in part, through the up-regulation of PI3K/Akt and ERK signaling pathways. ► Depletion of TACC3 reverses EMT.