MiR-206 inhibits gastric cancer proliferation in part by repressing CyclinD2

► MiR-206 expression is down-regulated in gastric cancer. ► MiR-206 can repress cell growth and induce cell cycle arrest at G0/G1 phase. ► MiR-206 could inhibit the proliferation of GC partly through down-regulating CylinD2. ► MiR-206 is a promising tumor suppressor in gastric cancer.