Helicobacter pylori decreases p27 expression through the delta opioid receptor-mediated inhibition of histone acetylation within the p27 promoter

► H. pylori decreases p27 expression by modulating the DOR and thereby inhibiting histone acetylation of the p27 promoter. ► H. pylori directly decreases phosphorylation of delta-opioid receptor in gastric epithelical cell. ► Decreased p27 in H. pylori infection accelerate cell turnover.