کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10900170 1084626 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
'Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer'
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
'Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer'
چکیده انگلیسی
Seprase is a membrane-bound serine proteinase with gelatinase activity, which may be involved in cancer invasion and metastasis. We examined seprase expression in colorectal cancer specimens obtained from 109 patients. Seprase immunoreactivity was found in cancer cells and adjacent stromal cells. Immunoblotting showed higher levels of seprase protein in colorectal cancer tissue than in normal colorectal tissue. A semiquantitative assessment of the immunohistochemistry results revealed a significant correlation between seprase expression and lymph node metastasis. These results suggested that an abundant expression of seprase in colorectal cancer tissue is associated with lymph node metastasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 227, Issue 2, 28 September 2005, Pages 229-236
نویسندگان
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