کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10900200 | 1084628 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tumor suppressive effects of tocotrienol in vivo and in vitro
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tumor suppressive effects of tocotrienol in vivo and in vitro Tumor suppressive effects of tocotrienol in vivo and in vitro](/preview/png/10900200.png)
چکیده انگلیسی
Tocotrienols have been reported to have higher biological activities than tocopherols. We investigated the antitumor effect of tocotrienols both in vivo and in vitro. Oral administration of tocotrienols resulted in significant suppression of liver and lung carcinogenesis in mice. In human hepatocellular carcinoma HepG2 cells, δ-tocotrienol exerted more significant antiproliferative effect than α-, β-, and γ-tocotrienols. δ-Tocotrienol induced apoptosis, and also tended to induce S phase arrest. On the other hand, gene expression analysis showed that δ-tocotrienol increased CYP1A1 gene, a phase I enzyme. Although further study will be necessary to investigate possible adverse effect, the data obtained in present study suggest that tocotrienols could be promising agents for cancer prevention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 229, Issue 2, 18 November 2005, Pages 181-191
Journal: Cancer Letters - Volume 229, Issue 2, 18 November 2005, Pages 181-191
نویسندگان
Sayori Wada, Yoshiko Satomi, Michiaki Murakoshi, Noriko Noguchi, Toshikazu Yoshikawa, Hoyoku Nishino,