کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10900361 | 1084638 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Rats (FLF1) were pretreated with 2 and 20Â mg/kg/day fluvastatin (Flu), and after 6 weeks, hepatocellular tumor cells were inoculated under the left renal capsule. At different times, growth and pyruvate kinase (PK) activity of the primary tumors and lymph node metastases were determined. Flu had a dose-dependent inhibitory effect on primary and metastatic tumors, and the inhibitiory effect on growth and PK activity in metastases were higher than in primary tumors. Finally, Flu had an earlier inhibitory effect on the early appeared PK activity in metastases than in primary tumors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 222, Issue 1, 10 May 2005, Pages 17-22
Journal: Cancer Letters - Volume 222, Issue 1, 10 May 2005, Pages 17-22
نویسندگان
György Paragh, Gabriella Fóris, György Jr, Ildikó Seres, Zsolt Karányi, Péter Fülöp, Zoltán Balogh, Béla Kosztáczky, Farkas Teichmann, Pál Kertai,