کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10900363 | 1084638 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
pH dependent uptake of porphyrin-type photosensitizers by solid tumor cells in vitro is not induced by modification of transmembrane potential
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: pH dependent uptake of porphyrin-type photosensitizers by solid tumor cells in vitro is not induced by modification of transmembrane potential pH dependent uptake of porphyrin-type photosensitizers by solid tumor cells in vitro is not induced by modification of transmembrane potential](/preview/png/10900363.png)
چکیده انگلیسی
The uptake of HpIX, TPPS2a and mTHPC by WiDr, THX cells and skin fibroblasts at pH 7.4 and 6.8 was compared. In the absence of serum, the uptake of HpIX was higher at lower pH. The difference was significant in WiDr cells (P<0.01) and skin fibroblasts (P<0.05). TPPS2a nor mTHPC showed any pH dependent uptake. Lowering the extracellular pH resulted in a significant depolarization (3-8Â mV) of the cells. Application of tetraethylammonium chloride did not affect the cellular uptake of any of the photosensitizers. We conclude that the pH dependent uptake of photosensitizers is not mainly related to altered transmembrane potential.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 222, Issue 1, 10 May 2005, Pages 39-47
Journal: Cancer Letters - Volume 222, Issue 1, 10 May 2005, Pages 39-47
نویسندگان
Beata ÄunderlÃková, Johan Moan, Ivar Sjaastad,