کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10900384 | 1084639 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 221, Issue 2, 28 April 2005, Pages 191-200
Journal: Cancer Letters - Volume 221, Issue 2, 28 April 2005, Pages 191-200
نویسندگان
Young Yang, Jeong-Hyung Lee, Kun Yong Kim, Hyun Keun Song, Jae Kwang Kim, Suk Ran Yoon, Daeho Cho, Kyu Sang Song, Young Ho Lee, Inpyo Choi,