کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10900404 | 1084641 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach](/preview/png/10900404.png)
چکیده انگلیسی
To explore whether DNA polymerase beta (pol β) contributes to the malignant transformation of gastric mucosa, we examined pol β in gastric tumor cell lines, primary tumors and precancerous lesions. Point mutations of pol β were detected in 6 of 13 cell lines and 23 of 104 tissues including 35.0% (14/40) of gastric cancer (GC), 30.0% (3/10) of dysplasia (Dys), 28.6% (4/14) of intestinal metaplasia (IM) and 10.5% (2/19) of chronic atrophic gastritis (CAG), respectively. A frequent mutation was a T to C transition at nucleotide 889, which was observed in 4 GC cell lines, 7 GC, 2 Dys, and 2 IM. The level of pol β expression in tumors was higher than that of their matched normal tissues and gradual changes from GC, Dys, CAG to IM. These results indicate that the mutation and overexpression of pol β may influence the progression during gastric carcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 220, Issue 1, 18 March 2005, Pages 101-114
Journal: Cancer Letters - Volume 220, Issue 1, 18 March 2005, Pages 101-114
نویسندگان
Xiao-Hui Tan, Min Zhao, Kai-Feng Pan, Ying Dong, Bin Dong, Gui-Jian Feng, Guang Jia, You-Yong Lu,