کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10900464 1084646 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women
چکیده انگلیسی
The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case-control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24-1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 218, Issue 2, 10 February 2005, Pages 191-197
نویسندگان
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