کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10901912 | 1084724 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Retro-inverso bradykinin opens the door of blood-brain tumor barrier for nanocarriers in glioma treatment
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Retro-inverso bradykinin opens the door of blood-brain tumor barrier for nanocarriers in glioma treatment Retro-inverso bradykinin opens the door of blood-brain tumor barrier for nanocarriers in glioma treatment](/preview/png/10901912.png)
چکیده انگلیسی
The blood-brain barrier and the blood-brain tumor barrier (BBTB) prevent most drugs entering brain tumors. Complicated preparation procedures of drug delivery systems and damage to normal brain tissue have limited the application of many strategies for the treatment of brain tumor in clinical trials. We have designed a bradykinin analog, retro-inverso bradykinin (RI-BK), which is characterized by resistance to proteolysis and high binding activity with the bradykinin type 2 (B2) receptor. After systemic administration, RI-BK binds to B2 receptors and induces a change in zonula occluden-1 and depolymerization of F-actin to selectively open the BBTB. RI-BK increased the accumulation of drug-loaded nanocarriers in the glioma but not in normal brain. Co-administration with RI-BK enhanced the therapeutic efficiency of drug-loaded nanocarriers for glioma. These findings suggest that RI-BK could be translated into the clinic as an adjunctive treatment for malignant brain tumors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 369, Issue 1, 1 December 2015, Pages 144-151
Journal: Cancer Letters - Volume 369, Issue 1, 1 December 2015, Pages 144-151
نویسندگان
Zuoxu Xie, Qing Shen, Cao Xie, Weiyue Lu, Chunmei Peng, Xiaoli Wei, Xue Li, Bingxia Su, Chunli Gao, Min Liu,