کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10902357 1084747 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advances in targeted therapy for unresectable melanoma: New drugs and combinations
ترجمه فارسی عنوان
پیشرفت در درمان هدفمند برای ملانوم غیر قابل درمان: داروهای جدید و ترکیبات
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Melanoma is the most deadly cutaneous cancer primarily derived from melanocytes with a poor prognosis in advanced stage. The therapy regimen for early stage melanoma patients is surgical resection with adjuvant IFN-alpha-2b therapy. For metastatic lesions, standard chemotherapy such as dacarbazine (DTIC) has not achieved a satisfying response rate. Therefore, new approaches to manage this deadly disease are highly expected to enhance the cure rate and to extend clinical benefits to patients with unresectable melanoma. Fortunately, the targeted therapeutic drugs and immunotherapy such as vemurafenib, dabrafenib, ipilimumab, and trametinib have shown their special advantage in the treatment of advanced melanoma. This article is to overview the advances in targeted therapy for unresectable melanoma patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 359, Issue 1, 1 April 2015, Pages 1-8
نویسندگان
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