کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10902378 | 1084747 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endostar attenuates melanoma tumor growth via its interruption of b-FGF mediated angiogenesis
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کلمات کلیدی
HUVECSMVDb-FGFAngiogenesis - آنژیوژنزEndostar - اندستارMicrovessel density - تراکم MicrovesselMelanoma - خال سرطانی یا ملانوماTargeted therapy - درمان هدفمندVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Vascular endothelial cell growth factor - فاکتور رشد سلول اندوتلیال عروقیbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایهTAF - می دانم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To develop optimal therapeutics is one of the hotspots in both clinical and basic melanoma studies. Previous studies indicate that fibroblast growth factors (b-FGF/FGF-2), an angiogenesis inducer beyond VEGF, might be a potential drug target in melanoma. As a novel anti-angiogenesis peptide drug, Endostar has shown promising therapeutic efficacy in non-small cell lung cancer. However, the effect of Endostar on b-FGF-induced angiogenesis in melanoma is unraveled. To this end, both in vivo and in vitro experiments were conducted and it was found that treatment of Endostar could inhibit tumor growth, which was accompanied by decreased micro-vessel density and serum b-FGF levels in a mouse melanoma model. In addition, treatment with Endostar in blood vessel endothelial cells could reduce their proliferation, cell migration and tube formation capacity in a dosage-dependent manner. Moreover, treatment of Endostar could also attenuate b-FGF-activated phosphorylation of p38 and ERK1/2 in HUVECs. These findings indicate that Endostar might exert its anti-tumor effect via suppressing b-FGF-induced angiogenesis and b-FGF-activated MAPK signaling pathway, suggesting that Endostar might be a potential choice for clinical melanoma treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 359, Issue 1, 1 April 2015, Pages 148-154
Journal: Cancer Letters - Volume 359, Issue 1, 1 April 2015, Pages 148-154
نویسندگان
Lijia Xiao, ShuCai Yang, Jianhua Hao, Xue Yuan, Wei Luo, Liping Jiang, Yang Hu, Zhongping Fu, Yun Zhang, Chang Zou,