کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10902422 1084793 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma
چکیده انگلیسی
The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor. We present two more ESS with MEAF6/PHF1 detected by transcriptome sequencing (case 1) and RT-PCR (case 2), proving that this fusion is recurrent in ESS. The transcript of both cases was an in-frame fusion between exon 5 of MEAF6 and exon 2 of PHF1. Both genes are involved in epigenetic modification, and this may well be their main pathogenetic theme also in ESS tumorigenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 347, Issue 1, 28 May 2014, Pages 75-78
نویسندگان
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