کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10902427 1084793 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells
چکیده انگلیسی
TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3′UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 347, Issue 1, 28 May 2014, Pages 98-104
نویسندگان
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