Humanized VB22B minibody for human Mpl stimulates human megakaryopoiesis but does not enhance platelet aggregation

We found that huVB22B, eltrombopag, and thrombopoietin have different effects on megakaryopoiesis, platelet function, and intracellular signaling. The precise mechanisms for these different biological effects regarding stimulation through the same receptor, Mpl, remain to be elucidated.