Effect of eosinophil cationic protein (ECP) on Hodgkin lymphoma cell lines

ECP is cytotoxic for HL tumor cells even at low concentrations, but heterogeneity between cell lines exists and not all tumor cells are eradicated. Two cell lines of B-cell origin, KMH2 and L428, were sensitive to ECP in a dose−response manner, but for HDLM-2, which is of T-cell origin, the cytotoxicity reached a plateau.