Differential effects of a novel IFN-ζ/limitin and IFN-α on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes

Weaker signals for Crk and Daxx may participate in less megakaryocyte suppressive activity of IFN-ζ/limitin and may distinguish IFN-ζ/limitin from IFN-α in megakaryocytes. Our results extend the understanding about thrombocytopenia in patients with IFN-α treatment as well as the possibility for the clinical application of human homologue of IFN-ζ/limitin or an engineered cytokine with useful features of the IFN-ζ/limitin structure.